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Friday, February 12, 2010

DRUGS THAT DISRUPT MICROTUBULES

Colchicine, colcemid, and nocadazol inhibit polymerization by binding to tubulin and preventing its addition to the plus ends. The figure to the right shows this inhibition by colchicine (red). Vinblastine and vincristine aggregate tubulin and lead to microtubule depolymerization. Taxol stabilizes microtubules by binding to a polymer. 

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