PROTEIN SCIENCES (BIOMOLECULAR)

Protein Purification is a popular protein science service offered by Blue Sky Biotech.
Other protein science services included but are not limited to the following:

• FPLC: IEC, IMA, SEC, AC, Buffer-exchange, etc.
• Microsome preparation
• Tissue/organ extraction and purification
• Antibody purification
• Development of multi-step protocols
• Activity validation (where applicable)
• QC supported by MASS Spec service
• QC by Western Blot and SDS PAGE

Purified recombinant protein is indispensable for drug discovery.  In the early stages of drug discovery, recombinant protein is used for target validation, enzyme characterization, high-throughput screening (HTS), and structural study.  In order to understand a disease target, pharmaceutical scientists must study its interaction with substrates.  For this purpose, researchers need active protein free of impurities which could interfere with their study of its mechanism.  Purity and activity of the recombinant protein are essential:  a pure, active enzyme gives a clean signal and reproducible results.
Blue Sky employees have worked in the Protein Science department of a major pharmaceutical company.  This group and others like it serve almost as "core facilities" in that they provide made-to-order proteins for enzyme characterization, structural study, and HTS.  Our experience in this environment gives us a unique understanding of the requirements for quality, purity, and activity of recombinant proteins. Customers of Blue Sky may rest assured that all purified proteins provided by this firm will meet the most exacting standards.
Protein expression, purification, and characterization are very precise, difficult disciplines.  We at Blue Sky have the expertise to generate the high-quality protein reagents which you need.